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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL3
All Species:
13.94
Human Site:
S557
Identified Species:
23.59
UniProt:
Q8IVW4
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IVW4
NP_001107047.1
592
67514
S557
E
S
K
K
T
E
S
S
K
I
P
T
L
L
N
Chimpanzee
Pan troglodytes
XP_517934
592
67566
S557
E
S
K
K
T
E
S
S
K
I
P
T
L
L
N
Rhesus Macaque
Macaca mulatta
XP_001108660
592
67612
S557
E
S
K
K
T
D
S
S
K
I
P
T
L
L
N
Dog
Lupus familis
XP_850612
456
51739
N445
S
S
N
L
M
A
S
N
P
N
S
N
L
S
H
Cat
Felis silvestris
Mouse
Mus musculus
Q8BLF2
595
67720
S559
E
S
K
K
T
D
S
S
K
I
P
T
L
L
S
Rat
Rattus norvegicus
Q9JM01
593
67534
P559
E
S
K
K
T
D
S
P
K
I
P
T
L
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512927
637
71445
P558
R
V
R
Q
T
P
Y
P
L
F
L
A
T
V
A
Chicken
Gallus gallus
P13863
303
34670
K292
P
Y
F
D
D
L
D
K
S
T
L
P
A
N
L
Frog
Xenopus laevis
P35567
302
34487
D291
H
P
Y
F
D
D
L
D
K
S
S
L
P
D
N
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
N339
E
N
R
R
N
Y
N
N
L
R
K
F
N
Y
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23572
297
34420
Y286
K
D
I
L
E
H
P
Y
F
N
G
F
Q
S
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784044
926
104004
G576
I
A
N
Q
S
D
H
G
G
H
G
F
N
A
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
E283
I
T
A
R
Q
A
L
E
H
E
Y
F
K
D
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
E283
I
N
A
R
A
A
L
E
H
E
Y
F
K
D
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.9
67.7
N.A.
80.5
79
N.A.
57.7
25
24.3
31
N.A.
23.4
N.A.
N.A.
30.2
Protein Similarity:
100
99.8
99.6
72.1
N.A.
89.7
87.6
N.A.
68.9
34.9
35.6
43
N.A.
35.1
N.A.
N.A.
44
P-Site Identity:
100
100
93.3
20
N.A.
86.6
80
N.A.
6.6
0
13.3
6.6
N.A.
0
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
33.3
N.A.
100
93.3
N.A.
26.6
0
20
46.6
N.A.
6.6
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
22.8
N.A.
23.1
N.A.
N.A.
Protein Similarity:
N.A.
33.9
N.A.
33.9
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
15
0
8
22
0
0
0
0
0
8
8
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
8
15
36
8
8
0
0
0
0
0
22
0
% D
% Glu:
43
0
0
0
8
15
0
15
0
15
0
0
0
0
0
% E
% Phe:
0
0
8
8
0
0
0
0
8
8
0
36
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
8
0
15
0
0
0
8
% G
% His:
8
0
0
0
0
8
8
0
15
8
0
0
0
0
15
% H
% Ile:
22
0
8
0
0
0
0
0
0
36
0
0
0
0
0
% I
% Lys:
8
0
36
36
0
0
0
8
43
0
8
0
15
0
0
% K
% Leu:
0
0
0
15
0
8
22
0
15
0
15
8
43
36
22
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
15
15
0
8
0
8
15
0
15
0
8
15
8
36
% N
% Pro:
8
8
0
0
0
8
8
15
8
0
36
8
8
0
0
% P
% Gln:
0
0
0
15
8
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
8
0
15
22
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
8
43
0
0
8
0
43
29
8
8
15
0
0
15
15
% S
% Thr:
0
8
0
0
43
0
0
0
0
8
0
36
8
0
0
% T
% Val:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
8
0
0
8
8
8
0
0
15
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _